Invitrogen™ RPL14 Polyclonal Antibody

Description

Immunogen sequence: KKMRNRIIKN EVKKLQKAAL LKASPKKAPG TKGTAAAAAA AAAAAAAAAK VPAKKITAAS KKAPAQKVPA QKATGQKAAP APKAQKGQKA PAQKAPAPKA S Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 73%.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Aoki M., Diabetes 45:157-164(1996). Tanaka M., Biochem. Biophys. Res. Commun. 243:531-537(1998). Yoshihama M., Genome Res. 12:379-390(2002).