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Invitrogen™ RUNX1 Monoclonal Antibody (RXDMC), PE, eBioscience™
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Product Code. 15239359
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Quantity:
25 μg
Unit Size:
25µg
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Product Code. Quantity unitSize
15239359 25 μg 25µg
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Product Code. 15239359 Supplier Invitrogen™ Supplier No. 12981680

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Description

Rat Monoclonal Antibody

Description: This RXDMC monoclonal antibody reacts with human and mouse Runx1, which is also known as AML1. This 50-kDa transcription factor is expressed in hematopoietic cells such as myeloid, T, and B cells, but not erythroid cells. Furthermore, Runx1 can be detected in nearly all non-hematopoietic tissues except the brain and heart. Runx1 is involved in several stages of T cell development, including the CD4-CD8- double negative (DN) to CD4+CD8+ double positive (DP) transition and commitment to the CD4 lineage. In addition to its role in thymocyte development, Runx1 has also been implicated in Th2 differentiation and immune homeostasis via direct interaction with Foxp3 in CD4+CD25+ regulatory T cells. Runx1 also affects Th2 differentiation by negatively regulating Gata-3 expression. Finally, the AML1 gene, which encodes Runx1, is a frequent target of translocations in acute myeloid leukemia. In humans, alternative splicing results in the generation of eleven isoforms. In mice, five isoforms exist as a result of alternative splicing; isoform 4 (aka AML1-C) is the most highly expressed in hematopoietic cells. Sequence analysis indicates that the RXDMC antibody recognizes isoform 4 in mouse and all human isoforms except AML-1FA, AML-1FB, and AML-1FC. Applications Reported: This RXDMC antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This RXDMC antibody has been tested by intracellular staining and flow c...

RUNX1 belongs to the mammalian RUNX family of DNA binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX1 is essential for hematopoietic stem cell generation in the vascular regions of the aorta, vitelline and umbilical arteries, yolk sac and placenta. RUNX1 is expressed in all tissues except brain and heart, with highest levels in thymus, bone marrow and peripheral blood.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RUNX1
Applications Flow Cytometry
Classification Monoclonal
Clone RXDMC
Concentration 0.2 mg/mL
Conjugate PE
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene RUNX1
Gene Accession No. Q01196, Q03347
Gene Alias acute myeloid leukemia 1 protein; Acute myeloid leukemia 2 protein; acute myeloid leukemia 3 protein; acute myeloid leukemia gene 2; AML1; AML-1; aml1 oncogene; AML1-EVI-1; AML1-EVI-1 fusion protein; AML2; AML3; AMLCR1; CBF2alpha; CBFA1; CBFA2; CBFA3; CBF-alpha 2; CBF-alpha-1; CBF-alpha-2; CBF-alpha-3; CCD; CCD1; CLCD; core binding factor alpha 2; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); Core-binding factor subunit alpha-1; Core-binding factor subunit alpha-2; core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 1; core-binding factor, runt domain, alpha subunit 2; core-binding factor, runt domain, alpha subunit 3; EVI-1; Oncogene AML-1; oncogene AML-2; Oncogene AML-3; OSF2; OSF-2; osteoblast-specific transcription factor 2; OTTHUMP00000108697; OTTHUMP00000108700; OTTHUMP00000108702; PEA2 alpha C; PEA2aA; PEA2-alpha A; PEA2-alpha B; PEA2-alpha C; PEBP2 alpha C; PEBP2A; Pebp2a2; PEBP2A3; PEBP2aA; PEBP2aB; PEBP2aC; PEBP2alpha; PEBP2-alpha A; PEBP2-alpha B; PEBP2-alpha C; Pebpa2b; polyomavirus enhancer-binding protein 2 alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha B subunit; polyomavirus enhancer-binding protein 2 alpha C subunit; RUN1; runt domain, alpha subunit 2; runt related transcription factor 1; runt related transcription factor 2; runt related transcription factor 3; runt-related transcription factor 1; Runt-related transcription factor 2; runt-related transcription factor 3; Runx1; RUNX1/ZNF687 fusion; RUNX2; RUNX3; SL3/AKV core-binding factor alpha A subunit; SL3/AKV core-binding factor alpha B subunit; SL3/AKV core-binding factor alpha C subunit; SL3-3 enhancer factor 1 alpha A subunit; SL3-3 enhancer factor 1 alpha B subunit; SL3-3 enhancer factor 1 alpha C subunit; transcription factor; transcription factor AML2
Gene Symbols RUNX1
Host Species Rat
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12394, 861
Target Species Human, Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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