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Invitrogen™ RUNX1/RUNX1T1 Polyclonal Antibody
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Product Code. 15596761
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Quantity:
100 μL
Unit Size:
100µL
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15596761 100 μL 100µL
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Product Code. 15596761 Supplier Invitrogen™ Supplier No. PA540076

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Description

Rabbit Polyclonal Antibody

RUNX1/RUNX1T1 Polyclonal Antibody for Western Blot, ChIP, ChIP-seq, ELISA

AML1/Runx1 binds DNA as a monomer and through the Runt domain. DNA binding is increased by heterodimerization with CBFB. Isoform AML1L can neither bind DNA nor heterodimerize and interferes with the transactivation activity of AML1/Runx1. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T cell receptor enhancers, LCK, IL3 and GMCSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. AML1/Runx1 is expressed in all tissues examined except brain and heart, and is expressed at the highest levels in thymus, bone marrow and peripheral blood. Defects in AML1/Runx1 are the cause of familial platelet disorder with associated myeloid malignancy, an autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RUNX1/RUNX1T1
Applications ChIP Assay, ChIP sequencing (ChIP-seq), ELISA, Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation whole serum with 0.05% sodium azide
Gene RUNX1
Gene Accession No. Q01196, Q06455
Gene Alias acute myelogenous leukemia 1 translocation 1, cyclin-D related; acute myeloid leukemia 1 protein; AML1; aml1 oncogene; AML1-EVI-1; AML1-EVI-1 fusion protein; AML1-MTG8; AML1T1; AMLCR1; CBF2alpha; CBFA2; CBFA2T1; CBFA2T1 isoform r1t1-11a61; CBFA2T1 isoform r1t1-11a62; CBFA2T1 isoform r1t1-11a63; CBFA2T1 isoform r1t1-11a64; CBFA2T1 isoform r1t1-11a65; CBFA2T1 isoform r1t1-7a47; CBFA2T1 isoform r1t1-7a48; CBFA2T1 isoform r1t1-7a49; CBFA2T1 isoform r1t1-7a50; CBFA2T1 isoform r1t1-7a51; CBFA2T1 isoform r1t1-7a52; CBFA2T1 isoform r1t1-7d53; CBFA2T1 isoform r1t1-7d54; CBFA2T1 isoform r1t1-7d55; CBFA2T1 isoform r1t1-7d56; CBFA2T1 isoform r1t1-8a57; CBFA2T1 isoform r1t1-8a58; CBFA2T1 isoform r1t1-8a59; CBFA2T1 isoform r1t1-8a60; CBF-alpha-2; CDR; Core-binding factor subunit alpha-2; core-binding factor, runt domain, alpha subunit 2; core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related; Cyclin-D-related protein; Eight twenty one protein; ETO; EVI-1; MTG8; myeloid translocation gene on 8q22; oncogene AML-1; PEA2-alpha B; PEBP2aB; PEBP2alpha; PEBP2-alpha B; polyomavirus enhancer-binding protein 2 alpha B subunit; Protein CBFA2T1; Protein ETO; Protein MTG8; runt related transcription factor 1; runt related transcription factor 1; translocated to, 1 (cyclin D related); runt-related transcription factor 1; runt-related transcription factor 1; translocated to, 1 (cyclin D-related); RUNX1; RUNX1 translocation partner 1; RUNX1/ZNF687 fusion; RUNX1T1; SL3/AKV core-binding factor alpha B subunit; SL3-3 enhancer factor 1 alpha B subunit; transcription factor; zinc finger MYND domain-containing protein 2; ZMYND2
Gene Symbols RUNX1, RUNX1T1
Host Species Rabbit
Immunogen KLH-conjugated synthetic peptide corresponding to human AML1-ETO fusion protein.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 861, 862
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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