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RWDD3 Monoclonal Antibody (OTI2A4), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA811762
This item is not returnable.
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Description
RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Ikappa-Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-a-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikappa-Beta increased stability. RSUME-enhanced sumoylation of Ikappa-Beta leads to the inhibition of NF-kappa-Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.Specifications
| RWDD3 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q9Y3V2 | |
| RWDD3 | |
| Human recombit protein fragment corresponding to amino acids 1-267 of human RWDD3 produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| OTI2A4 | |
| Unconjugated | |
| RWDD3 | |
| RSUME | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 25950 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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