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Invitrogen™ RWDD3 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA534884

Product Code. 15308951

  • € 520.00 / 100µL

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Description

Description

Recommended positive controls: 293T, A431, HeLa, HepG2. Predicted reactivity: Human (99%), Rhesus Monkey (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Ikappa-Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-a-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikappa-Beta increased stability. RSUME-enhanced sumoylation of Ikappa-Beta leads to the inhibition of NF-kappa-Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

RWDD3
Polyclonal
Unconjugated
RWDD3
2510027J23Rik; 3110037C01Rik; AI035684; AI662458; pituitary tumor X2CR1 protein; RSUME; RWD domain containing 3; RWD domain-containing protein 3; RWD domain-containing sumoylation enhancer; RWD-containing sumoylation enhancer; Rwdd3; X2cr1
Rabbit
Antigen affinity chromatography
RUO
25950
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot
1 mg/mL
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Q9Y3V2
RWDD3
Recombinant protein encompassing a sequence within the center region of human RWDD3. The exact sequence is proprietary.
100 μL
Primary
Human
Antibody
IgG
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