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Invitrogen™ SARS-CoV-2 NSP5 Recombinant Rabbit Monoclonal Antibody (HL1367)
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Product Code. 17809335
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
17809335 100 μL 100µL
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Product Code. 17809335 Supplier Invitrogen™ Supplier No. MA547017

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Description

Rabbit Recombinant Monoclonal Antibody

Store as concentrated solution. Centrifuge briefly prior to opening vial.

SARS-CoV-2 NSP5 is a non-structural protein in which the main protease targets RIG-I and mitochondrial antiviral signaling (MAVS) protein via two distinct mechanisms for inhibition. NSP5 cleaves off the 10 most-N-terminal amino acids from RIG-I and deprives it of the ability to activate MAVS, whereas NSP5 promotes the ubiquitination and proteosome-mediated degradation of MAVS. NSP5 potently inhibits interferon (IFN) induction by double-stranded RNA (dsRNA) in an enzyme-dependent manner.
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Specifications

Antigen SARS-CoV-2 NSP5
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone HL1367
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene ORF1ab
Gene Accession No. P0DTD1
Gene Alias COVID-19 Envelope; SARS-CoV-2; SARS-CoV-2 Envelope
Gene Symbols ORF1ab
Host Species Rabbit
Immunogen Recombinant fragment of SARS-CoV-2 (COVID-19) 3CLpro (nsp5).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 43740578
Target Species Virus
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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