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Invitrogen™ SASS6 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA531301
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Description
Recommended positive controls: A549, HeLa, HepG2, HCT116. Predicted reactivity: Human (99%), Mouse (88%), Rat (92%), Chicken (83%), Bovine (93%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
Specifications
| SASS6 | |
| Polyclonal | |
| Unconjugated | |
| SASS6 | |
| 2810453L12Rik; HsSAS-6; MCPH14; RGD1306255; SAS6; SAS-6; SAS-6 centriolar assembly protein; Sass6; spindle assembly 6 homolog; spindle assembly 6 homolog (C. elegans); spindle assembly abnormal protein 6 homolog | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 163786 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
| Q6UVJ0 | |
| SASS6 | |
| Recombinant protein encompassing a sequence within the center region of human SASS6. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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