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STEMCELL Technologies SB203580 (Hydrochloride)

Product Code. 17160042
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5 mg
Unit Size:
5mg
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17160042 5 mg 5mg
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Product Code. 17160042 Supplier STEMCELL Technologies Supplier No. 72222

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Description

p38 MAPK inhibitor

  • SB203580 (Hydrochloride) is a potent inhibitor of p38 MAPK activity (IC50 = 0.6 μM)
  • It inhibits both the α and β isoforms of p38 MAPK, and does not inhibit ERK or JNK
  • (Bain et al.), Cuenda et al.)
  • Enhances the growth and self-renewal of mouse embryonic stem (ES) cells (Qi et al.)
  • Promotes long-term maintenance of human naïve ground state pluripotent stem cells (Gafni et al.)
  • Promotes proliferation of human endothelial progenitor cells (Seeger et al.)
  • Promotes proliferation of neonatal and adult rat cardiomyocytes (Engel et al.)
  • Enhances differentiation of cardiomyocytes from human ES cells (Gaur et al.), Graichen et al.)
  • Inhibits differentiation of cardiomyocytes from mouse ES cells by inhibition of early mesoderm (Davidson and Morange)

Specifications

CAS 869185-85-3
Synonym PB 203580; RWJ 64809
Quantity 5 mg
Molecular Formula C21H16FN3OS · HCl
Purity ≥98%
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