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SCF Polyclonal Antibody, Biotin, PeproTech®, Invitrogen™

Product Code. 17825633
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17825633 2 x 500 μg 1mg
17854923 25 μg 25µg
17815823 50 μg 50µg
30054694 500 μg 500µg
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Product Code. 17825633 Supplier Invitrogen Supplier No. 500P202BT1MG

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Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: MQEICRNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV THLSVSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVAC MEENAPKNVK ESLKKPETRN FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Rat SCF. Anti-Rat SCF-specific antibody was purified by affinity chromatography and then biotinylated. Sandwich ELISA: To detect rat SCF by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.25-1.0 μg/mL of this antibody is required. This biotinylated polyclonal antibody, in conjunction with PeproTech Polyclonal Anti-Rat SCF (500-P202) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant rat SCF. Western Blot: To detect Rat SCF by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Rat SCF is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions. 500-P202BT-1MG will be provided as 2 x 500 μg

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SCF
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugate Biotin
Formulation PBS with no preservative
Gene KITLG
Gene Accession No. P21581
Gene Alias 710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF
Gene Symbols KITLG
Host Species Rabbit
Immunogen E.coli-derived, 18.4 kDa Recombinant Rat SCF
Purification Method Antigen affinity chromatography
Quantity 2 x 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 60427
Target Species Rat
Content And Storage -20°C
Form Lyophilized
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