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Invitrogen™ SESN1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA550132
This item is not returnable.
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Description
The antibody detects endogenous levels of total SESN1 protein.
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Specifications
| SESN1 | |
| Polyclonal | |
| Unconjugated | |
| Sesn1 | |
| 1110002G11Rik; AU044290; LOW QUALITY PROTEIN: sestrin-1; p53 activated gene 26; p53 regulated PA26 nuclear protein; p53-regulated protein PA26; PA26; Sesn1; Sest1; sestrin 1; sestrin-1; si:ch211-51a19.4; WITHDRAWN: zgc:103669; zgc:103669; zgc:91970 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 27244, 294518 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q9Y6P5 | |
| Sesn1 | |
| Synthesized peptide derived from internal of human SESN1 (aa 271-320). | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |
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