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Invitrogen™ SETD6 Monoclonal Antibody (GT688)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA527851
This item is not returnable.
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Description
Positive Control: K562, THP-1, HL-60 Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
SETD6 (SET domain-containing protein 6) is a 473 amino acid protein that belongs to the SETD6 family. Containing one SET domain, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. SETD6 is a proteinlysine N-methyltransferase that specifically monomethylates Lys-310 of the NFκB p65 subunit of NFκB complex, leading to down-regulate NFκB transcription factor activity. SETD6-mediated methylation renders NFκB p65 inert and attenuates NFκB p65-driven transcriptional programs, including inflammatory responses in primary immune cells. The SETD6-initiated lysine-methylation signaling cascade acts to restrain activation of NFκB-mediated inflammatory responses in diverse cell types.
Specifications
| SETD6 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 20% glycerol and no preservative; pH 7 | |
| Q8TBK2 | |
| SETD6 | |
| Recombinant protein encompassing a sequence within the center region of human SETD6. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG2b |
| Immunohistochemistry (Paraffin), Western Blot | |
| GT688 | |
| Unconjugated | |
| SETD6 | |
| 0610039J04Rik; 3110004G14Rik; AI413388; C76402; N-lysine methyltransferase SETD6; RGD1560538; SET domain containing 6; SET domain-containing protein 6; SETD6 | |
| Mouse | |
| Protein G | |
| RUO | |
| 79918 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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