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Invitrogen™ SFPQ Monoclonal Antibody (B92)

Product Code. 11524922
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Quantity:
50 μL
Unit Size:
50µL
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Product Code. Quantity unitSize
11524922 50 μL 50µL
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Product Code. 11524922 Supplier Invitrogen™ Supplier No. MA125325

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Description

Mouse Monoclonal Antibody

Recommended positive controls: HeLa. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SFPQ
Applications Immunohistochemistry (Frozen), Immunoprecipitation, Radioimmune Assays (RIA), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone B92
Concentration 2.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene SFPQ
Gene Accession No. P23246, Q8VIJ6
Gene Alias 100 kDa DNA-pairing protein; 1110004P21Rik; 2810416M14Rik; 5730453G22Rik; 9030402K04Rik; AU021830; D4Ertd314e; DNA-binding p52/p100 complex, 100 kDa subunit; Gm12940; hPOMp100; NonO/p54nrb homolog; OTTMUSG00000009329; polypyrimidine tract binding protein associated; polypyrimidine tract-binding protein-associated splicing factor; polypyrimidine tract-binding protein-associated-splicing factor; POMP100; PPP1R140; protein phosphatase 1, regulatory subunit 140; PSF; PTB-associated splicing factor; PTB-associated-splicing factor; REP1; Sfpq; splicing factor proline and glutamine rich; splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated); splicing factor proline/glutamine rich (polypyrimidine tract-binding protein-associated); splicing factor proline/glutamine-rich; splicing factor, proline- and glutamine-rich
Gene Symbols SFPQ
Host Species Mouse
Immunogen Lysate of mouse bone marrow-derived stromal cell line.
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6421, 71514
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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