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SHARPIN Monoclonal Antibody (OTI2B1), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA811608
This item is not returnable.
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Description
Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.Specifications
| SHARPIN | |
| Monoclonal | |
| Unconjugated | |
| SHARPIN | |
| SIPL1 | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 81858 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Western Blot | |
| OTI2B1 | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q9H0F6 | |
| SHARPIN | |
| Human recombit protein fragment corresponding to amino acids 1-326 of human SHARPIN produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
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