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SHARPIN Mouse anti-Human, Clone: OTI1F4, liquid, TrueMAB™

Product Code. 17555714
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Quantity:
100 μL
Unit Size:
100µL
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17555714 100 μL 100µL
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Product Code. 17555714 Supplier Origene Technologies Supplier No. TA811607

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Description

Mouse Monoclonal Antibody

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.

Specifications

Antigen SHARPIN
Applications Western Blot
Classification Monoclonal
Clone OTI1F4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene SHARPIN
Gene Accession No. Q9H0F6
Gene Alias SIPL1
Gene Symbols SHARPIN
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 1-326 of human SHARPIN produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 81858
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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