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Invitrogen™ SHISA4 Polyclonal Antibody
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Product Code. 17824640
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
17824640 100 μL 100µL
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Product Code. 17824640 Supplier Invitrogen™ Supplier No. PA5140121

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Description

Rabbit Polyclonal Antibody

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: RQQLQSPFEG QEIPMTGIPV QPVYPYPQDP QAGPA Highest antigen sequence indentity to the following orthologs: Mouse - 86%, Rat - 83%.

SHISA4 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SHISA4
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SHISA4
Gene Accession No. Q96DD7
Gene Alias 9330132O05Rik; C1orf40; mShisa4; Protein shisa-4; shisa family member 4; shisa homolog 4; SHISA4; Tmem58; transmembrane protein 58; UNQ583/PRO1153
Gene Symbols SHISA4
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SHISA4. Recombinant protein control fragment (Product #RP-109144).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 149345
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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