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Invitrogen™ SHMT2 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA532228

Product Code. 13476747

  • € 514.00 / 100µL

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This item is not returnable. View return policy

Description

Description

Recommended positive controls: 293T, HeLa, A431, HepG2. Predicted reactivity: Mouse (93%), Rat (91%), Xenopus laevis (81%), Rabbit (93%), Bovine (92%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SHMT2
Polyclonal
Unconjugated
SHMT2
2700043D08Rik; AA408223; AA986903; epididymis secretory sperm binding protein Li 51e; GLY A+; GLYA; glycine auxotroph A, human complement for hamster; glycine hydroxymethyltransferase; HEL-S-51e; mitochondrial serine hydroxymethyltransferase; serine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase; serine hydroxymethyltransferase 2; serine hydroxymethyltransferase 2 (mitochondrial); serine hydroxymethyltransferase, mitochondrial; Serine methylase; SHMT; SHMT 2; SHMT2; threonine aldolase
Rabbit
Antigen affinity chromatography
RUO
108037, 299857, 6472
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 20% glycerol and 0.01% thimerosal; pH 7
P34897, Q9CZN7
SHMT2
Recombinant protein encompassing a sequence within the N-terminus region of human SHMT2. The exact sequence is proprietary.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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