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Siglec-3/CD33 Antibody (WM53), DyLight 405, Novus Biologicals™

Mouse Monoclonal Antibody

Brand:  Novus Biologicals NBP2-34511V

Product Code. 18128233

  • € 577.00 / 0.10mL

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Description

Description

Siglec-3/CD33 Monoclonal specifically detects Siglec-3/CD33 in Human samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Siglec-3/CD33
Monoclonal
DyLight 405
CD33 antigen, CD33 antigen (gp67), CD33 molecule, FLJ00391, myeloid cell surface antigen CD33, p67, sialic acid binding Ig-like lectin 3, Sialic acid-binding Ig-like lectin 3, SIGLEC-3, SIGLEC3gp67
Mouse
67 kDa
0.1 mL
Immunology
945
Human
Purified
Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)
WM53
Flow Cytometry, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen
CD33
Human AML cells
Protein A or G purified
RUO
Primary
Recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immuno-receptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
Store at 4C in the dark.
IgG1 κ
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