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Invitrogen™ SIGLEC7 Monoclonal Antibody (D5), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA551105
This item is not returnable.
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Description
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Specifications
| SIGLEC7 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4 | |
| Q9Y286 | |
| SIGLEC7 | |
| Recombinant Human SIGLEC7 protein, Gln19-Ser336 (Accession #Q9Y286). | |
| 200 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG1 κ |
| Western Blot, Immunohistochemistry (Paraffin), Western Blot | |
| D5 | |
| Unconjugated | |
| SIGLEC7 | |
| Adhesion inhibitory receptor molecule 1; adhesion inhibitory receptor molecule 1, siglec-7; AIRM1; AIRM-1; CD328; CDw328; D-siglec; p75; p75/ AIRM-1; p75/AIRM1; QA79; QA79 membrane protein; sialic acid binding Ig like lectin 7; sialic acid binding Ig-like lectin 7; sialic acid binding immunoglobulin-like lectin 7; sialic acid-binding Ig-like lectin 7; Siglec; SIGLEC19P; SIGLEC7; SIGLEC-7; SIGLECP2 | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 27036 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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