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Invitrogen™ SIGLEC8 Recombinant Human Monoclonal Antibody (18D13)

Product Code. 30536170
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Quantity:
100 μL
Unit Size:
100µL
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30536170 100 μL 100µL
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Product Code. 30536170 Supplier Invitrogen™ Supplier No. MA560809

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Description

Human Recombinant Monoclonal Antibody

SIGLEC8 Recombinant Monoclonal Antibody for IHC (P), ELISA

SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3-linked sialic acid. and also binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIGLEC8
Applications ELISA, Immunohistochemistry (Paraffin)
Classification Recombinant Monoclonal
Clone 18D13
Concentration 1.94 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene SIGLEC8
Gene Accession No. Q9NYZ4
Gene Alias CDw329; MGC59785; SAF2; SAF-2; sialic acid binding Ig like lectin 8; sialic acid binding Ig-like lectin 8; sialic acid-binding Ig-like lectin 8; Sialoadhesin family member 2; Siglec; SIGLEC8; Siglec-8; SIGLEC8L
Gene Symbols SIGLEC8
Host Species Human
Immunogen Recombinant Human SIGLEC8 protein.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27181
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG1
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