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Invitrogen™ SIK3 Polyclonal Antibody
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Product Code. 15971395
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Quantity:
100 μg
Unit Size:
0.1mg
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15971395 100 μg 0.1mg
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Product Code. 15971395 Supplier Invitrogen™ Supplier No. PA572738

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Description

Chicken Polyclonal Antibody

SIK3 Polyclonal Antibody for Western Blot, ICC/IF, ELISA

SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm. Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer. There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer. SIK3 is a novel tumor-associated antigen (TAA). SIK3 is a positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SIK3
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SIK3
Gene Accession No. Q6P4S6, Q9Y2K2
Gene Alias 5730525O22Rik; 9030204A07Rik; AI447252; AI846254; AI849445; Kiaa0999; L19; mKIAA0999; QSK; Salt-inducible kinase 3; serine/threonine-protein kinase QSK; Serine/threonine-protein kinase SIK3; SIK family kinase 3; SIK3; SIK-3
Gene Symbols SIK3
Host Species Chicken
Immunogen SIK3 antibody for an 18 amino acid synthetic peptide near the carboxy terminus of human SIK3. The immunogen is within amino acids 1190 - 1240 of SIK3.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23387, 684112, 70661
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgY
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