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Invitrogen™ Human SIK3, GST Tag Recombinant Protein

Product Code. 15409033
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Quantity:
10 μg
100 μg
Unit Size:
100µg
10µg
This item is not returnable. View return policy

Product Code. 15409033

Brand: Invitrogen™ PV6403

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This item is not returnable. View return policy

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Recombinant human SIK3 (1-307) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Validated in LanthaScreen™ Kinase Binding Assay Protocols available for simple use and optimized performance Multiple pack sizes available for convenient use Related Product:LanthaScreen™ Eu Kinase Binding Assay Protein Form: Recombinant.

SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm. Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer. There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer. SIK3 is a novel tumor-associated antigen (TAA). SIK3 is a positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9Y2K2
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50mM tris HCl with 0.1mM PMSF, 25% glycerol, 0.1mM EDTA, 150mM NaCl, 10mM glutathione, 0.25mM DTT and no preservative; pH 7.5
Gene ID (Entrez) 23387
Molecular Weight (g/mol) 61.7 kDa
Name Human SIK3, GST Tag
pH Range 7.5
Purification Method Purified
Quantity 10 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias 5730525O22Rik; 9030204A07Rik; AI447252; AI846254; AI849445; Kiaa0999; L19; mKIAA0999; QSK; Salt-inducible kinase 3; serine/threonine-protein kinase QSK; Serine/threonine-protein kinase SIK3; SIK family kinase 3; SIK3; SIK-3
Common Name SIK3
Gene Symbol SIK3
Protein Length 59-365
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Sequence 59-365
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Assay Entry Biochemical binding/kinetic
Kinase Group Serine/Threonine Kinase
Target Entry SIK3
Expression System Baculovirus
Protein Family Kinases & Inhibitors
Protein Form Recombinant, Fragment
Form Liquid
Protein Subtype Serine/Threonine Kinases
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