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Simeprevir, MedChemExpress

Product Code. 16470117
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Product Code. 16470117 Supplier Medchem Express Supplier No. HY10241

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Description

MedChemExpress Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM.

Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses.

Specifications

Chemical Name or Material Simeprevir
Physical Form Solid
CAS 923604-59-5
Color Off-White
Quantity 50 mg
Purity Grade Notes Research
Molecular Formula C38H47N5O7S2
For Use With (Application) COVID-19-anti-virus
Synonym TMC435 TMC435350
Solubility Information DMSO : 14.29 mg/mL (19.05 mM; Need ultrasonic)
SMILES COC1=C(C)C2=C(C(O[C@H]3C[C@@H](C(N(C)CCCC/C=C\[C@H](C4)[C@]4(C(NS(=O)(C5CC5)=O)=O)N6)=O)[C@H](C6=O)C3)=CC(C7=NC(C(C)C)=CS7)=N2)C=C1
Molecular Weight (g/mol) 749.94
Formula Weight 749.94
Percent Purity 99.46%
Grade Research
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Research purposes only

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