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Invitrogen™ SIPA1L3 Polyclonal Antibody

Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5140165
Description
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: QPSGSFSTPG SATYVRYKPS PERYTAAPHP LLSLDPHFSH DGTSSGDSSS GGLTSQESTM ERQKPEPLWH VPAQARLSAI AGSSGNKHPS R Highest antigen sequence indentity to the following orthologs: Rat - 89%, Mouse - 89%.
Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.
Specifications
| SIPA1L3 | |
| Polyclonal | |
| Unconjugated | |
| SIPA1L3 | |
| 2610511M17Rik; CTRCT45; KIAA0545; signal induced proliferation associated 1 like 3; signal-induced proliferation-associated 1 like 3; signal-induced proliferation-associated 1-like protein 3; Sipa1l3; SIPA1-like protein 3; SPA-1-like 3; SPA-1-like protein 3; Spal3; SPAR3 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 23094 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry | |
| 0.3 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| O60292 | |
| SIPA1L3 | |
| Recombinant protein corresponding to Human SIPA1L3. Recombinant protein control fragment (Product #RP-109447). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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