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Invitrogen™ SIRT1 Polyclonal Antibody
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Chicken Polyclonal Antibody

Brand:  Invitrogen™ PA520964

Product Code. 12829112

  • € 566.00 / 100µg

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Description

Description

A suggested positive control is mouse liver tissue lysate. PA5-20964 can be used with blocking peptide PEP-1078.

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SIRT1
Polyclonal
Unconjugated
SIRT1
75SirT1; AA673258; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; SIR2; Sir2a; SIR2alpha; SIR2L1; sir2-like 1; SIR2-like protein 1; SIRT 1; SIRT1; SIRT-1; SirtT1 75 kDa fragment; sirtuin 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1
Chicken
Antigen affinity chromatography
RUO
23411, 309757, 93759
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Liquid
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
A0A0G2JZ79, Q923E4, Q96EB6
SIRT1
A 19 amino acid peptide near the amino terminus of human SIRT1.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgY
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