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STEMCELL Technologies Sirtinol

Product Code. 17120282
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10 mg
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17120282 10 mg 10mg
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Product Code. 17120282 Supplier STEMCELL Technologies Supplier No. 73824

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Description

Epigenetic modifier; Inhibitor of Sir2p, SIRT1, and SIRT2

  • Sirtinol is a cell-permeable inhibitor of sirtuin NAD+-dependent histone deacetylases (HDACs), including yeast Sir2p (IC50 = 68 μM; Grozinger et al.), human SIRT1 (IC50 = 131 μM; Schuetz et al.), and SIRT2 (IC50 = 38 μM; Grozinger et al.) It does not inhibit human HDAC1 activity (Grozinger et al.) Sirtinol also activates the auxin signaling pathway in Arabidopsis (Dai et al.)
  • Suppresses inflammatory signaling in human dermal microvascular endothelial cells (Orecchia et al.)
  • Enhances apoptosis and cell death in leukemic cells, but not in healthy leukocytes and hematopoietic progenitors (Cea et al.)
  • Induces senescence-like growth arrest in human cancer cell lines MCF-7 and H1299 (Ota et al.; Wang et al.)

Specifications

CAS 410536-97-9
Synonym Sir Two Inhibitor Naphthol
Quantity 10 mg
Molecular Formula C26H22N2O2
Purity ≥98%
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