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Invitrogen™ SLC16A2 Polyclonal Antibody
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Product Code. 16549091
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Quantity:
100 μL
Unit Size:
100µL
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16549091 100 μL 100µL
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Product Code. 16549091 Supplier Invitrogen™ Supplier No. PA596251

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MALQSQASEE AKGPWQEADQ EQQEPVGSPE PESEPEPEPE PEPVPVPPPE PQPEPQPLPD PAPLPELEFE SERVHEPEPT PTVETRGTAR GFQPPEGGFG; Positive Samples: LO2, HT-29, 293T, Mouse heart, Mouse kidney, Mouse liver, Rat heart, Rat liver; Cellular Location: Cell membrane, Multi-pass membrane protein.

Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT 1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. Defects in the gene encoding for MCT8, SLC16A2, can cause monocarboxylate transporter 8 deficiency (MCT8 deficiency), a defect in cellular hormone transport causing a severe form of X-linked psychomotor retardation and abnormal thyroid levels.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC16A2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.56 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Slc16a2
Gene Accession No. O70324, P36021, Q8K1P8
Gene Alias AHDS; AW105741; DXS128; DXS128E; MCT 7; MCT 8; MCT7; MCT8; monocarboxylate transporter; monocarboxylate transporter 7; Monocarboxylate transporter 8; Monocarboxylate transporter 8 (MCT 8) (X-linked PEST-containing transporter); MRX22; SLC16A2; solute carrier family 16 (monocarboxylic acid transporters), member 2; solute carrier family 16 member 2; solute carrier family 16, member 2 (monocarboxylic acid transporter 8); solute carrier family 16, member 2 (thyroid hormone transporter); X-linked PEST-containing transporter; XPCT
Gene Symbols Slc16a2
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20502, 259248, 6567
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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