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Invitrogen™ SLC24A2 Polyclonal Antibody
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Product Code. 18075711
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Quantity:
100 μL
Unit Size:
100µL
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18075711 100 μL 100µL
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Product Code. 18075711 Supplier Invitrogen™ Supplier No. PA5145209

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: TEEGRFREKA SILHKIAKKK CHVDENERQN GAANHVEKIE LPNSTSTDVE MTPSSDASEP VQNGNLSHNI EGAEAQTADE EEDQPLSLAW PSETRKQ Antigen sequence identity: Mouse 89%; Rat 81%.

NCKX2, also designated solute carrier family 24, member 2 (SLC24A2), belongs to a family of potassium-dependent sodium/calcium exchangers, all of which contain two large hydrophilic loops and two sets of multiple transmembrane-spanning segments. NCKX2 is expressed in neurons throughout the brain, with high expression found in cone photoreceptors in the retina as well as hippocampal pyramidal cells and the deep nuclei of the cerebellum. A critical component in the process of light adaptation, NCKX2 transports one calcium ion and one potassium ion in exchange for four sodium ions, thereby contolling calcium concentration in the eye during light and darkness. Additionally, NCKX2 regulates calcium levels in other cellular locations that experience rapid calcium fluxes, such as neuronal synapses. Inactivation of NCKX2 is believed to be an important regulatory mechanism in the control of sodium and calcium levels under different physiological conditions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC24A2
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Slc24a2
Gene Accession No. Q9UI40
Gene Alias 2810021B17Rik; 6330417K15Rik; AI847460; Na(+)/K(+)/Ca(2+)-exchange protein 2; Nckx2; potassium-dependent sodium-calcium exchanger; retinal cone Na-Ca+K exchanger; Slc24a2; Sodium/potassium/calcium exchanger 2; solute carrier family 24 (sodium/potassium/calcium exchanger), member 2; solute carrier family 24 member 2; solute carrier family 24, member 2
Gene Symbols Slc24a2
Host Species Rabbit
Immunogen Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 374-470.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25769
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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