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SMC1A Monoclonal Antibody (OTI3G4), TrueMAB™, OriGene

Product Code. 17532364
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100 μL
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17532364 100 μL 100µL
17552364 30 μL 30µL
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Product Code. 17532364 Supplier Origene Technologies Supplier No. TA809792

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Description

Mouse Monoclonal Antibody

Structural Maintece of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromo proteins are conserved in eukaryotes and lead to mitotic chromosome segregatior defects. This suggests a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. Mutations in the gene can lead to Cornelia de Lange syndrome 2.

Specifications

Antigen SMC1A
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI3G4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene SMC1A
Gene Accession No. Q14683, Q9CU62
Gene Alias CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Gene Symbols SMC1A
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 889-1016 of human SMC1A produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 24061, 8243
Target Species Human, Mouse
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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