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Invitrogen™ SMC6 Polyclonal Antibody
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Product Code. 15576862
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Quantity:
100 μL
Unit Size:
100µL
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15576862 100 μL 100µL
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Product Code. 15576862 Supplier Invitrogen™ Supplier No. PA545522

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Description

Rabbit Polyclonal Antibody

Peptide sequence: MADSQRFRQF ILLTPQSMSS LPSSKLIRIL RMSDPERGQT TLPFRPVTQE Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 100%.

Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen SMC6
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene SMC6
Gene Accession No. Q96SB8
Gene Alias 2810489L22Rik; 3830418C19Rik; AA990493; AU018782; AW742439; hSMC6; Kiaa4103; mKIAA4103; mSMC6; SMC protein 6; Smc6; SMC-6; SMC6 structural maintenance of chromosomes 6-like 1; SMC6L1; structural maintenance of chromosomes 6; structural maintenance of chromosomes protein 6; Structural maintenance of chromosomes protein 6-like protein
Gene Symbols SMC6
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal of human SMC6 (aa 1036-1085).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79677
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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