Invitrogen™ SMN1/SMN2 Monoclonal Antibody (2B10)

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human placenta tissue, human SW620 whole cell, human PANC-1 whole cell, human HepG2 whole cell, human A549 whole cell, rat RH35 whole cell, mouse HEPA1-6 whole cell. IHC: human mammary cancer tissue, human mammary cancer tissue. ICC/IF: A431 Cell.

The SMN1 gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein - survival motor neuron protein. The SMN complex plays a catalyst role in the assemble of small nuclear ribonucleoproteins, the building blocks of the spliceosome. Mutations in the SMN1 gene are known to cause spinal muscular atrophy 1/2.