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Invitrogen™ SMPD4 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5143768

Product Code. 17826858

  • € 536.00 / 100µL

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Description

Description

The antibody detects an 85-90 kDa* band corresponding to nSMase3 on SDS-PAGE immunoblots of adult mouse heart and mouse C2C12 cells. The antibody works for western blot, ELISA, immunoprecipitation, and immunocytochemistry.

The protein encoded by SMPD4 is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SMPD4
Polyclonal
Unconjugated
SMPD4
4122402O22Rik; Kiaa1418; mKIAA1418; NET13; neutral membrane (neutral sphingomyelinase-3); neutral sphingomyelinase 3; Neutral sphingomyelinase III; neutral sphingomyelinase-3; NSMASE3; nSMase-3; RGD1310674; SKNY; SKNY protein; Smpd4; Sphingomyelin phosphodiesterase 4; sphingomyelin phosphodiesterase 4, neutral membrane; sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Rabbit
Antigen affinity chromatography
RUO
303790, 55627, 77626
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Immunoprecipitation, Western Blot, Immunocytochemistry
1 mg/mL
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Q6ZPR5, Q9NXE4
SMPD4
nSMase3 synthetic peptide corresponds to amino acids in the C-terminal region of mouse nSMase3. This sequence is highly conserved in rat and human nSMase3, and has low homology to other nSMase family members.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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