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SMURF2 Mouse anti-Human, Clone: OTI5E4, lyophilized, TrueMAB™

Product Code. 17608951
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
17608951 100 μg 100µg
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Product Code. 17608951 Supplier Origene Technologies Supplier No. CF806650

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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

Specifications

Antigen SMURF2
Applications Western Blot
Classification Monoclonal
Clone OTI5E4
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene SMURF2
Gene Accession No. Q9HAU4
Gene Alias SMAD specific E3 ubiquitin protein ligase 2
Gene Symbols SMURF2
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 151-440 of human SMURF2 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64750
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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