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Invitrogen™ Sorcin Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA523143

Product Code. 13267748

  • € 520.00 / 100µg

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This item is not returnable. View return policy

Description

Description

Sequence homology: Xenopus (93%), Opossum (87%), Chicken (81%).

Sorcin is a 198 amino acid, soluble, resistance-related, calcium-binding cytosolic protein belonging to the penta-EF hand (PEF) family of calcium binding proteins and contains 4 EF-hand calcium-binding motifs. Human Sorcin is known to share 95% sequence identity with hamster Sorcin. It is known to associate with the sarcolemmal proteins Annexin VII, cardiac ryanodine receptors and L-type Ca2+ channels and thus influence the intracellular Ca (2+)-homeostasis. It is also important in the regulation of intracellular Ca2+ cycling and Ca2+ influx pathways in the heart and skeletal muscle during excitation-contraction. It is overproduced in many multi-drug resistance (MDR) cells and regulates cell apoptosis pathways, thus acting as a new MDR marker for prognosis of acute myeloid leukemia (AML) and a good target for anti-MDR drug development.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Sorcin
Polyclonal
Unconjugated
Sri
22 kDa protein; 2210417O06Rik; 2900070H08Rik; calcium binding protein amplified in mutlidrug-resistant cells; CP22; CP-22; H_RG167B05.1; SCN; Sor; Sorcin; SRI; V19
Rabbit
Antigen affinity chromatography
RUO
100059619, 109552, 475220, 508319, 6717, 683667
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1.0 mg/mL
PBS with 0.02% sodium azide
P30626, Q6P069
Sri
Partial synthetic peptide made to an internal region of the human SRI protein (between amino acids 45-90).
100 μg
Primary
Human, Mouse, Rat, Canine, Monkey, Bovine, Horse
Antibody
IgG
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