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Invitrogen™ Sortilin Monoclonal Antibody (CL6526)
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Product Code. 16324884
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Quantity:
100 μL
Unit Size:
100µL
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16324884 100 μL 100µL
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Product Code. 16324884 Supplier Invitrogen™ Supplier No. MA531437

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Description

Mouse Monoclonal Antibody

Immunogen sequence: LERNCEEKDY TIWLAHSTDP EDYEDGCILG YKEQFLRLRK SSVCQNGRDY VVTKQPSICL CSLEDFLCDF GYYRPENDSK CVEQPELKGH DLEFCLYGRE EHLTTNGYRK IPGDKCQGGV NPVREVKD Highest antigen sequence indentity to the following orthologs: Mouse - 89%, Rat - 89%.

Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Sortilin
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone CL6526
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Sort1
Gene Accession No. Q6PHU5, Q99523
Gene Alias 100 kDa NT receptor; 2900053A11Rik; AI852375; Glycoprotein 110; glycoprotein 95; Gp110; Gp95; LDLCQ6; mNTR3; neurotensin receptor 3; NT3; NTR3; Nts3; Ntsr3; Sort1; Sortilin; sortilin 1
Gene Symbols Sort1
Host Species Mouse
Immunogen Recombinant protein fragment of Human SORT1 (Product #RP-88683)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20661, 6272
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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