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  6. SOX10 Mouse anti-Human, Mouse, Clone: SOX10/1074, Novus Biologicals™

SOX10 Mouse anti-Human, Mouse, Clone: SOX10/1074, Novus Biologicals™

Product Code. 18247231 Shop All Bio Techne Products
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18247231 100 μg 100µg
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Product Code. 18247231 Supplier Novus Biologicals Supplier No. NBP259622100UG

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Description

Mouse Monoclonal Antibody

SOX10 Monoclonal specifically detects SOX10 in Human, Mouse samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOX10
Applications Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), SDS-Page
Classification Monoclonal
Clone SOX10/1074
Concentration 0.2 mg/mL
Conjugate Unconjugated
Dilution Western Blot 0.5-1 ug/ml, Flow Cytometry 0.5-1 ug/million cells, Immunocytochemistry/Immunofluorescence 1-2 ug/ml, Immunohistochemistry-Paraffin 0.5-1 ug/ml, SDS-Page, Protein Array 1:100-1:2000
Formulation 10mM PBS with 0.05% BSA with 0.05% Sodium Azide
Gene Alias MGC15649, PCWH, SRY (sex determining region Y)-box 10, SRY-related HMG-box gene 10, transcription factor SOX-10, WS4C, WS4mouse, human homolog of
Gene Symbols SOX10
Host Species Mouse
Immunogen Recombinant human SOX10 protein fragment (around aa115-269) (exact sequence is proprietary)
Molecular Weight of Antigen 54 kDa
Purification Method Protein A or G purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6663
Test Specificity The specificity of this monoclonal antibody to its intended target was validated by HuProt Array, containing more than 19,000, full-length human proteins. Recognizes a protein of ∼55kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG -box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplasticmelanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
Target Species Human, Mouse
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG2b κ
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