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Invitrogen™ Spectrin beta-3 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA560406
This item is not returnable.
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Description
Immunogen sequence: RLWRFLWEVG EAEAWVREQQ HLLASADTGR DLTGALRLLN KHTALRGEMS GRLGPLKLTL EQGQQLVAEG HPGASQASA Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
Specifications
| Spectrin beta-3 | |
| Polyclonal | |
| Unconjugated | |
| Sptbn2 | |
| beta SpIII sigma 1; beta-III spectrin; beta-spectrin 3; glutamate transporter EAAT4-associated protein 41; GTRAP41; KIAA0302; mKIAA0302; SCA5; SCAR14; Spectrin Beta; spectrin beta 3; spectrin beta chain, brain 2; spectrin beta chain, non-erythrocytic 2; spectrin beta III sigma 2; spectrin beta, non-erythrocytic 2; spectrin, beta, non-erythrocytic 2; spectrin, non-erythroid beta chain 2; spectrin-like protein GTRAP41; spinocerebellar ataxia 5 protein; Spnb3; SPNB-3; SPTBN2 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 6712 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| O15020 | |
| Sptbn2 | |
| Recombinant protein corresponding to Human Spectrin beta-3. Recombinant protein control fragment (Product #RP-103863). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
Product Title
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