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SPP1 Monoclonal Antibody (OTI6C12), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA806238
This item is not returnable.
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Description
Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in maligt glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.Specifications
| SPP1 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| P10451 | |
| SPP1 | |
| Human recombit protein fragment corresponding to amino acids 17-314 of human SPP1 produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| OTI6C12 | |
| Unconjugated | |
| SPP1 | |
| BNSP, BSPI, ETA-1, OPN | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 6696 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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