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Invitrogen™ SPRTN Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA555226

Product Code. 15703151

  • € 566.00 / 100µL

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Description

Description

Immunogen sequence: SHQNVLSNYF PRVSFANQKA FRGVNGSPRI SVTVGNIPKN SVSSSSQRRV SSSKISLRNS SKVTESASVM PSQDVSGSED T Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 55%.

SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SPRTN
Polyclonal
Unconjugated
SPRTN
C1orf124; DDDL1880; dJ876B10.3; DNA damage protein targeting VCP; DNA damage-targeting VCP (p97) adaptor; DVC1; Gm505; PRO4323; protein with SprT-like domain at the N terminus; RGD1559496; spartan; sprT-like domain-containing protein Spartan; SprT-like N-terminal domain; Sprtn; UNQ1880/PRO4323; zinc finger RAD18 domain-containing protein
Rabbit
Antigen affinity chromatography
RUO
83932
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunocytochemistry
0.1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q9H040
SPRTN
Recombinant protein corresponding to Human SPRTN. Recombinant protein control fragment (Product #RP-93978).
100 μL
Primary
Human
Antibody
IgG
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