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Invitrogen™ SPSB1 Polyclonal Antibody
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Product Code. 17148353
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Quantity:
100 μL
Unit Size:
100µL
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17148353 100 μL 100µL
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Product Code. 17148353 Supplier Invitrogen™ Supplier No. PA5110426

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MGQKVTGGIK TVDMRDPTYR PLKQELQGLD YCKPTRLDLL LDMPPVSYDV QLLHSWNNND RSLNVFVKED DKLIFHRHPV AQSTDAIRGK VGYTRGLHVW QITWAMRQRG THAVVGVATA DAPLHSVGYT TLVGNNHESW GWDLGRNRLY HDGKNQPSKT YPAFLEPDET FIVPDSFLVA LDMDDGTLSF IVDGQYMGVA FRGLKGKKLY PVVSAVWGHC EIRMRYLNGL DPEPLPLMDL CRRSVRLALG RERLGEIHTL PLPASLKAYL LYQ.

Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPSB1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.39 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SPSB1
Gene Accession No. Q9D5L7
Gene Alias 1110014L01Rik; 4930422J18Rik; AI596360; AI854583; CBG; fi35c01; hypothetical protein LOC334190; novel SPRY domain containing protein; RGD1309319; splA/ryanodine receptor domain and SOCS box containing 1; SPRY domain-containing SOCS box protein 1; SPRY domain-containing SOCS box protein SSB-1; Spsb1; SSB1; SSB-1; Unknown (protein for IMAGE:8228399); wu:fi35c01; zgc:114115
Gene Symbols SPSB1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-273 of human SPSB1 (Q96BD6).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 74646
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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