missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 18786766

Tocris Bioscience™ StemRegenin 1
GREENER_CHOICE

Product Code. 18786766
Click to view available options
Quantity:
10 mg
Unit Size:
10mg
This item is not returnable. View return policy

Product Code. 18786766

Brand: Tocris Bioscience™ 7086/10

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment

StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC50 = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemReginin 1 promotes the expansion of CD34+ cells ex vivo. In hematopoietic stem cell (HSC) culture, the compound induces a 50-fold increase in CD34-expressing cells, and HSCs cultured with StemReginin 1 show increased engraftment in mice. Combination of StemReginin 1 with DMOG (Cat. No. 4408) increases the proportion of primitive HSCs and improves long-term engraftment. The product also promotes expansion of human promyelocytic leukemia cell line NB4.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9 H-purin-6-yl]amino]ethyl]phenol
CAS 1227633-49-9
Quantity 10 mg
Target Aryl Hydrocarbon Receptor Antagonists
Molecular Formula C24H23N5OS
Purity 0.98
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.