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Invitrogen™ STIM1 Polyclonal Antibody

Product Code. 16589501
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Quantity:
100 μL
Unit Size:
100µL
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16589501 100 μL 100µL
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Product Code. 16589501 Supplier Invitrogen™ Supplier No. PA596668

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RQRVAPKPPQ MSRAADEALN AMTSNGSHRL IEGVHPGSLV EKLPDSPALA KKALLALNHG LDKAHSLMEL SPSAPPGGSP HLDSSRSHSP SSPDPDTPSP VGDSRALQAS RNTRIPHLAG KKAVAEEDNG SIGEETDSSP GRKKFPLKIF KKPLKK; Positive Samples: LO2, Jurkat, BxPC-3, HeLa, Mouse brain, Mouse heart, Mouse kidney; Cellular Location: Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Single-pass type I membrane protein, cytoskeleton.

STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
TRUSTED_SUSTAINABILITY

Specifications

Antigen STIM1
Applications ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.75 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene STIM1
Gene Accession No. P70302, P84903, Q13586
Gene Alias D11S4896E; GOK; IMD10; RGD:1306831}; SIM; Stim1; stim1 {ECO:0000312; STIM1L; STRMK; Stromal interaction molecule 1; stromal interaction molecule 1 precursor; TAM; TAM1
Gene Symbols STIM1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 530-685 of human STIM1 (NP_0031472).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20866, 361618, 6786
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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