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Invitrogen™ STIM1 Recombinant Rabbit Monoclonal Antibody (SD0814)
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Product Code. 16395784
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Quantity:
100 μL
Unit Size:
100µL
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16395784 100 μL 100µL
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Product Code. 16395784 Supplier Invitrogen™ Supplier No. MA532376

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Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
TRUSTED_SUSTAINABILITY

Specifications

Antigen STIM1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone SD0814
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
Gene STIM1
Gene Accession No. P70302, P84903, Q13586
Gene Alias D11S4896E; GOK; IMD10; RGD:1306831}; SIM; Stim1; stim1 {ECO:0000312; STIM1L; STRMK; Stromal interaction molecule 1; stromal interaction molecule 1 precursor; TAM; TAM1
Gene Symbols STIM1
Host Species Rabbit
Immunogen Recombinant protein within Human Stromal aa 561-685.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20866, 361618, 6786
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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