Invitrogen™ Streptococcus pneumoniae CPS Monoclonal Antibody (0492)

Description

Specificity: Reactive with the Strep. pneumoniae common C-polysaccharide. Purified preparations consist of >90% pure mouse monoclonal antibody which has been purified from ascites fluid by protein A chromatography. The final preparation is formulated to a protein concentration of 100 μg/mL in 0.01 M phosphate buffered saline, pH 7.2 and contains 0.1% sodium azide. Each vial contains 1.0 mL. This product contains no stabilizing proteins and should be stored at 4C until ready for use. Working dilution must be determined by the user. Suggested starting ranges are 1:10-1:50 for ICC/IF and 1:20-1:200. for ELISA.

There are more than 85 antigenic types of S. pneumoniae, which are determined by capsule antigens. Altough S. pneumoniae is part of the normal respiratory flora, invasion commonly results in pneumonia as well as meningitis. S. pneumoniae is protected from phagocytosis by its polysaccharide capsule which is also a prominent virulence factor. Infections can usually be treated with antibiotics, although resistant strains are emerging.