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  8. SU 6668, Tocris Bioscience™

SU 6668, Tocris Bioscience™
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Product Code. 18085152
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Quantity:
10 mg
50 mg
Dimensione della confezione:
10mg
50mg
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Codice prodotto. 18085152

Marca: Tocris Bioscience 3335/10

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Description

PDGFR, VEGFR and FGFR inhibitor

ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC50 values are 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 values are 0.41, 9.3 and 16.5 μM for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo. Exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapoptotic activity and is orally active.
TRUSTED_SUSTAINABILITY

Identifiants chimiques

CAS 252916-29-3
Molecular Formula C18H18N2O3
Molecular Weight (g/mol) 310.353
InChI Key NHFDRBXTEDBWCZ-NTEUORMPSA-N
Synonym 3-2,4-dimethyl-5-e-2-oxo-1h-indol-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, e-3-2,4-dimethyl-5-2-oxoindolin-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, tsu 68, tsu-68 su6668,orantinib, 3-2,4-dimethyl-5-3e-2-oxo-1h-indol-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, 3-2,4-dimethyl-5-e-2-oxo-1,2-dihydro-3h-indol-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, tsu-68 random configuration, z-3-2,4-dimethyl-5-2-oxoindolin-3-ylidene-methyl-1h-pyrrol-3-yl propanoic acid, 3-2,4-dimethyl-5-2-oxoindolin-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, 5-1,2-dihydro-2-oxo-3h-indol-3-ylidene methyl-2,4-dimethyl-1h-pyrrole-3-propanoic acid
PubChem CID 5995546
IUPAC Name 3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
SMILES CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O

Spécification

Quantity 10 mg
Formula Weight 310.35
Percent Purity >99%
Chemical Name or Material SU 6668
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