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Invitrogen™ Syntaphilin Monoclonal Antibody (M371)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA547739
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Description
This antibody detects a 70 kDa* protein corresponding to the molecular mass of Syntaphilin on SDS-PAGE immunoblots of adult mouse brain.
Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Multiple isoforms are known to exist.
Specifications
| Syntaphilin | |
| Monoclonal | |
| 0.25 mg/mL | |
| PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide | |
| B5DF41, O15079, Q80U23 | |
| SNPH | |
| Clone M371 was generated from a sequence corresponding to amino acids in the N-terminal region of human syntaphilin. This sequence has high homology to mouse and rat syntaphilin. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG1 |
| Western Blot | |
| M371 | |
| Unconjugated | |
| SNPH | |
| 6430515A01; AW045671; AW556958; AW743098; bA314N13.5; KIAA0374; mKIAA0374; Snph; Syntaphilin | |
| Mouse | |
| Protein A | |
| RUO | |
| 241727, 296267, 9751 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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