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Invitrogen™ T4S20 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA566779
This item is not returnable.
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Description
Immunogen sequence: IHPESFNLQWF FNDSCAPPTG FNKPTSNDTM ASGWRASSFH FDSEENKHRL IHFSV Highest antigen sequence identity to the following orthologs - mouse 52%, rat 52%.
Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).
Specifications
| T4S20 | |
| Polyclonal | |
| Unconjugated | |
| TM4SF20 | |
| PRO994; SLI5; TCCE518; TM4SF20; transmembrane 4 L six family member 20; transmembrane 4 L6 family member 20; UNQ518/PRO994 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 79853 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q53R12 | |
| TM4SF20 | |
| Recombinant protein fragment of Human TM4SF20 (Product #RP-104287) | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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