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Invitrogen™ TAB182 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA558171
This item is not returnable.
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Description
Immunogen sequence: DWTPDLGLRN MAPGAVCSPG ESKELGVGQM DWGNNLGLRD LEVTCDPDSG GSQGLRGCGV GQMDWTQDLA PQNVELFGAP SEARE Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 76%.
TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.
Specifications
| TAB182 | |
| Polyclonal | |
| Unconjugated | |
| TNKS1BP1 | |
| 182 kDa tankyrase-1-binding protein; KIAA1741; TAB182; tankyrase 1 binding protein 1; tankyrase 1 binding protein 1, 182kDa; tankyrase 1-binding protein of 182 kDa; testis secretory sperm-binding protein Li 206a; TNKS1BP1 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 85456 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 0.2 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q9C0C2 | |
| TNKS1BP1 | |
| Recombinant protein corresponding to Human TAB182. Recombinant protein control fragment (Product #RP-97362). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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