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TAK-659 hydrochloride, MedChemExpress

Product Code. 16445927
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Product Code. 16445927

Brand: Medchem Express HY100867A

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Description

MedChemExpress TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL).

TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL).

Specifications

Chemical Name or Material TAK-659 hydrochloride
CAS 1952251-28-3
Color White
Purity Grade Notes Research
Molecular Formula C17H22ClFN6O
Quantity 5 mg
Solubility Information H2O : 2 mg/mL (5.25 mM; ultrasonic and adjust pH to 3 with HCl) ∣DMSO : < 1 mg/mL (insoluble or slightly soluble)
SMILES FC1=C(N[C@@H]2CCCC[C@@H]2N)N=C(C3=CN(C)N=C3)C4=C1CNC4=O.Cl
Molecular Weight (g/mol) 380.85
Formula Weight 380.85
Percent Purity 98.13%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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