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  8. TAK-960 dihydrochloride, MedChemExpress

TAK-960 dihydrochloride, MedChemExpress

Product Code. 16446338
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Product Code. 16446338

Brand: Medchem Express HY15160B

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Description

MedChemExpress TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. TAK-960 dihydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 dihydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts.

TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. TAK-960 dihydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 dihydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts.

Specifications

Chemical Name or Material TAK-960 dihydrochloride
Color White
Purity Grade Notes Research
Molecular Formula C27H36Cl2F3N7O3
Quantity 10 mg
Solubility Information H2O : 10 mg/mL (15.76 mM; Need ultrasonic) ∣DMSO : 3.23 mg/mL (5.09 mM; Need ultrasonic)
SMILES [H]Cl.O=C(NC1CCN(C)CC1)C2=CC(OC)=C(NC3=NC=C(N4C)C(N(C5CCCC5)CC(F)(F)C4=O)=N3)C=C2F.[H]Cl
Molecular Weight (g/mol) 634.52
Formula Weight 634.52
Percent Purity 99.81%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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