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Invitrogen™ TAK1 Polyclonal Antibody
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Product Code. 16374635 Shop All Thermo Scientific Products
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100 μg
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100µg
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16374635 100 μg 100µg
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Product Code. 16374635 Supplier Invitrogen™ Supplier No. PA595370

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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human MCF-7 whole cell, human A431 whole cell, human A374 whole cell, rat heart tissue, mouse heart tissue, mouse NIH/3T3 whole cell. ICC/IF: SiHa cell. Flow: U87 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

TAK1 (also known as MAP3K7), a part of the serine/threonine kinase family, is a versatile protein with many signaling functions. Originally identified as a TGF- beta-activated kinase, TAK1 interacts with TGF- beta-receptor and TRAF6 to modulate TGF- beta activation of JNK and p38. It has additional roles in activation of p38 and JNK through Wnt, BMP, and activin signaling pathways as well in response to thyroid hormone, osmotic stress, endothelin, and ephrine. Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin beta1 and integrin beta5, promoting proper wound healing. TAK1 also plays an essential role in IKK activation in numerous signaling pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the C-terminal region of TAK1 and becomes polyubiquitinated, TAK1 is autophosphorylated at Thr178, Thr184, Thr187 and Ser192, and finally TAK1 phosphorylates IKK- beta. Additionally, TAK1 represses human telomerase reverse transcriptase suggesting a role in regulation of cell lifespan.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TAK1
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and no preservative
Gene MAP3K7
Gene Accession No. O43318, P0C8E4, Q62073
Gene Alias B430101B05; C87327; hypothetical protein LOC553788; I79_000697; M3K7; map3k7; map3k7.L; MAPKKK; MEKK7; mitogen activated protein kinase kinase kinase 7; mitogen-activated protein kinase kinase kinase 7; mitogen-activated protein kinase kinase kinase 7 L homeolog; RP1-154G14.1; si:ch211-225h9.1; Tak1; TAK1z; TGF1a; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; TGF-beta-activated kinase TAK1; transforming growth factor beta-activated kinase 1; transforming growth factor-beta-activated kinase 1; XELAEV_18027270mg; xTAK1; zgc:110612
Gene Symbols MAP3K7
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human TAK1 (566-603aa RLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQ).
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26409, 313121, 6885
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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